Desmethylanethol trithione

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

ADT-OH 是茴香脑二硫代硫酮 (ADT) 和合成硫化氢 (H2S) 供体的衍生物。

ADT-OH is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. In the in vitro glucose-oxygen deprivation (OGD) model, ADT-OH markedly attenuated tPA-enhanced Akt activation and VEGF expression in brain microvascular endothelial cells. Finally, ADT-OH improved functional outcomes in mice subjected to MCAO and tPA infusion. H2S donors reduced tPA-induced cerebral hemorrhage by possibly inhibiting the Akt-VEGF-MMP9 cascade. Administration of H2S donors has potential as a novel modality to improve the safety of tPA following stroke.

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ADT-OH | Desmethylanethol trithione | ACS1

PI3K/Akt/mTOR signaling

S6 Kinase

Akt| VEGFR

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18274-81-2

226.33

C9H6OS3

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (552.27 mM)

c1cc(O)ccc1c1cc(=S)ss1

5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione

(-20℃)

With Ice Pack

≥ 2 years